The Yankees beat the Twins in both games of a doubleheader at Yankee Stadium on Wednesday.
The Yankees won the first game, 5-4 in 12 innings, but they lost the second game, 7-1.
The Twins are now tied with the White Sox for second place in the American League Central. They are two games behind the Guardians, who are in first place.
"It was a long, tough day," Twins manager Rocco Baldelli said. "The second game didn't go as planned. Most likely, there wasn't much to get excited about.
In the first game, I thought we played well, put ourselves in a good position, and had a few chances to win.
We did a lot of things well, but we could have done some things better. But overall, losing both games is a tough way to end the day.
But nothing could ruin Twins right-hander Louie Varland's first game in the major leagues.
He is the first player born in Minnesota to start for the Twins since right-handed pitcher Cole De Vries made two starts in 2013.